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Studies in animal models show that ipamorelin produces a dose-dependent GH release that reaches a plateau without the cortisol and prolactin co-release seen with GHRP-6 and other less selective GHRPs

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J Clin Endocrinol Metab 83:20012005 OLone R, Frith MC, Karlsson EK, Hansen U (2004) Genomic targets of nuclear estrogen receptors