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Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial

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These PL-PUFAs are then oxidized by iron-dependent enzymes as lipoxygenases (LOXs) or the labile iron pool into lipid hydroperoxides (PL-PUFA-OOH) to undergo the Fenton reaction under the presence of ferrous iron to trigger ferroptosis onset (Xl et al., 2022)

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