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As a master antioxidant, glutathione may contribute to skin health by reducing oxidative stress and its associated hyperpigmentation

Oral semaglutide amplifies these natural effects

Laboratory data showed that S-acetyl glutathione increased intracellular glutathione and had a positive effect on many oxidative stress biomarkers

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In the db/db mouse model, local administration of GLP1RAs reverses diabetes-induced downregulation of GLAST (glutamate-aspartate transporter), reduces extracellular glutamate accumulation, and activates anti-apoptotic signalling pathways such as Bcl2 and AKT, thereby inhibiting the expression of apoptotic factors such as iNOS, FasL, and caspase8 [62, 64]