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Whole-blood measurements are dominated by erythrocyte glutathione and require appropriate volume- or erythrocyte-based normalization, whereas plasma and serum contain much lower concentrations and are particularly sensitive to hemolysis and processing delay

Glutathione shifts the process of melanogenesis from eumelanin to pheomelanin through the reaction between thiol and dopaquinone groups causing formation of sulfhydryl-dopa conjugates[] [Figure 2]

Healthy endothelial function and nitric oxide signaling depend on adequate glutathione levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Nuttall SL, Martin U, Sinclair AJ, Kendall MJ

J Exp Bot 65(5):12591270