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2) Engagement is linked to longer medication program persistence and stronger renewal In a separate January 2026 analysis focused on persistence, members in the top quartile of engagement were, on average, on a GLP-1 medication program for over twice as long (2.2x) within the first 12 months as those in the bottom quartile

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Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ

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This activation of the macrophages and PMN results in a positive feedback mechanism, as the modified erythrocytes trigger its continuous activation with the generation of ROS