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The medication is typically initiated at a low dose of 0.25 mg weekly, with gradual titration to therapeutic doses of 0.5 mg, 1 mg, or 2 mg weekly, depending on individual response and tolerability
However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al
This includes sedatives used for the short-term treatment of insomnia or benzodiazepine medications, which exert effects on benzodiazepine receptors, a class of agents that work in the central nervous system to slow it down
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