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The mechanism may involve IGF1 LR3s effects on cartilage and synovial tissue, as IGF-1 receptors are present in these tissues and the peptide can influence their body function

The reasonable reading is that cagrilintides gastrointestinal effects are mechanism-based and generally manageable with titration in the studied populations, but that manageable in trials is not the same as fully characterized for long-term real-world use, and the delayed-emptying mechanism itself carries context-specific cautions that should not be waved away

It can be used to induce animal models of kidney disease

Therefore, cancer patients should not take alpha-lipoic acid (or any supplement) without consulting their oncologist

doi: 10.1038/s41467-024-48330-0 27 KahntA