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CRTC family The cAMP response element binding protein (CREB) has been documented to function in association with a family of co-activators known as cAMP-regulated transcriptional co-activators (CRTCs)

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[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, the following respiratory effects, infections, or related symptoms were reported in patients receiving 50 mg per day vs