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There are also differences in how these medications work and their effectiveness

Post-marketing surveillance has included reports of: Irritability Mood changes Emotional flattening Anxiety However: These reports are uncommon They do not prove causation They often involve other contributing factors After reviewing these reports, both the FDA and European Medicines Agency concluded there is no clear causal linkbetween GLP-1 medications and serious mood or behavioral disorders, but they recommend clinical monitoring, especially in patients with a psychiatric history

It can have many causes, including diabetes, which is a reason many people take drugs

Kumar M, Ranjan R, Dandapat S, Srivastava R, Sinha MP

"Zepbound (tirzepatide) Pharmacy Coverage Policy." Effective 1/20/2025, reviewed 8/20/2025