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Glutathione is a powerful antioxidant naturally found inside the body, especially in the liver, where it plays an important role in protecting cells from damage caused by free radicals

It is a 53-amino-acid polypeptide weighing roughly 6,200 Daltons, which immediately makes it too large to cross intact stratum corneum at meaningful concentrations

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Liu LY, Ye R, Lin, et al

Additionally, studies on TM cross-reactivity with mites and insects underscore TMs role in IgE cross-reactivity, although recent research indicates that T-cell cross-reactivity is limited and appears to depend more on protein structural stability than on amino acid sequence identity [49]