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It is used in in vitro research to study copper-dependent enzyme activation, extracellular matrix remodeling, and broad-spectrum gene expression modulation

Common dosing guidelines for Topiramate include: Starting dose: The initial dose is often 25 mg per day, and it may be gradually increased depending on how you respond to the medication

Injections in the trial were administered subcutaneously into the abdomen, upper thigh, or upper arm, with site rotation between doses

10.1016/j.kint.2022.12.028 32 WannerC.InzucchiS

Lu S, Kanekura K, Hara T et al (2014) A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome