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Patients With Hepatic Impairment Hepatic impairment does not have any impact on the exposure of semaglutide

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Semaglutide (Ozempic and Wegovy) is a selective GLP-1 (glucagon-like peptide-1) receptor agonist

Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close

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