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However, in the case of hypermobile EDS, no genetic marker has yet been discovered, which adds to the complexity of diagnosis and research

The latest Rome IV classification [4] defines CVS as stereotypical episodes of vomiting regarding onset (acute) and duration (less than 1 week), with 2 or more episodes in the past 6 months, occurring at least 1 week apart, with return to baseline health between cycles and which cannot be attributed to another condition

(4) Pharmacokinetics: Isoproterenol is administered parenterally, has a short duration of action, and is rapidly metabolized primarily by catechol-O-methyltransferase (COMT)

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