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Patients with lower genetic GLP-1 receptor sensitivity may experience faster hunger rebound from missed doses, making schedule consistency even more critical for their success

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According to the review, [GLP-1 receptor] signaling in astrocytes regulates both central and peripheral metabolism, extending from energy balance to neuroplasticity. This signaling also enhances neuron growth, and an increase in astrocytes also increases neuron survival

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As someone with a history of Crohns, a type of inflammatory bowel disease (IBD), I already deal with a lot of GI issues