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In the first few weeks of treatment, many GLP-1 users experience digestive discomfort, including nausea, vomiting, diarrhea, and stomach pain.6 More often than not, these are related to a GLP-1 receptor agonists ability to slow gastric emptying

To further investigate the anti-inflammatory effects of liraglutide and determine if the GLP-1R signaling pathway is involved in its anti-inflammatory effects, exendin fragment 939, a competitive GLP-1R antagonist was added to the incubation

"One disappointing aspect is that a patient might get started on these drugs, then they might stop for a month or two and then they might find another company that pops up that might give them these medications and all the while, no one's really addressing what's going on holistically with these types of patients who actually probably need to get plugged in and need to get an appropriate workup and diagnosis to make sure it's appropriate and get that kind of whole person care," she said