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Evidence Rating Level: 1 (Excellent) Study Rundown: There is strong overlap between weight gain and type 2 diabetes, with the majority of diabetic patients being overweight or obese by BMI measures

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For example, beyond restoring glomerular pressure toward more normal physiological levels, hemodynamic effects in the systemic circulation induced by natriuresis restore relative euvolemia, lower blood pressure and arterial stiffness, and may contribute to improving cardiac preload and afterload [13,14]

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