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doi: 10.1111/j.1756-185X.2009.01375.x

Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes

In line with metabolomic data, these findings indicate sustained glutamine metabolism, consistent with the significant rescue of mitochondrial respiration observed in patient NPs when glutamine was used as the sole respiratory substrate (Figs

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Scientific interest in these compounds focuses on understanding their biological activity, molecular signalling, cellular responses, and interactions with physiological pathways involved in tissue biology