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At immature mossy-fiber-CA3 synapses, correlated presynaptic and postsynaptic activity persistently enhances GABA release and network excitability via BDNF and cAMP-dependent PKA

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Reactive astrocytes protect the CNS by releasing neurotrophic factors (for example, NGF, TGF-, LIF and BDNF) and cytokines that promote neuronal survival and create an anti-inflammatory environment 46,47

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