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1 GLP-1 medications act by helping the body release more insulin when blood sugar is high and reduce the release of glucagon, a hormone that raises blood sugar

Prespecified subgroup analyses were stratified by duration of GLP1-RA or DPP4i use (at least 6-months, 1-year, and 2-years of use) within their respective groups

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However, this strategy is not universally effective, as the medication's long half-life means side effects can occur at any time during the week

This weight regain is not due to medication "dependence" in the traditional sense, but rather reflects the underlying biology of obesity as a chronic condition