There was a statistically significant reduction in the primary endpoint, which was a composite of cardiovascular death or worsening HF events, with an RRR of 33%
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Nausea could be dose-limiting in some participants
The study found that semaglutide and tirzepatide, drugs widely prescribed for diabetes and obesity, were linked to lower RA disease activity, reduced pain, and better metabolic outcomes compared with patients who did not use them
672 GSK3174998 and BMS-986178, both of which are humanized IgG1 agonistic OX40 monoclonal antibodies, have very modest combination therapeutic activities with ICBs against advanced solid tumors, although with a tolerable safety profile