Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Still, most people move through a fairly predictable set of stages, and knowing them helps you set realistic expectations
When you are giving a B12 injection subcutaneously, you pinch the fat to make sure youre only penetrating the subcutaneous tissue (or the innermost layer of skin) and pull it away from the muscle, then insert the needle
AOD-9604 specifically targets fat metabolism without affecting blood sugar or insulin pathways, making it theoretically useful for patients who experience gastrointestinal side effects from GLP-1 medications like Semaglutide
And B12 isnt likely to boost energy unless youre deficient