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That three-pronged approach is what drives the 24.2% average weight loss at 48 weeks documented in Phase 2 trials, a number that approaches the outcomes typically associated with bariatric surgery

To improve the selectivity, in this work, we design and synthesize a malononitrile-functionalized TPE derivative, TPE-DCV, which can undergo addition reaction with thiol group to the alkene bond, leading to the change in its fluorescence in the system (Figure 1)

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Lennerz, B