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Hu G, Cassano PA

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TBK1 directly phosphorylates S403 of p62, which is required for the autophagic function of p62 in driving autophagosome maturation (187)

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In type 2 diabetes, it often outperforms older therapies on both blood sugar and weight, which is why it is quickly becoming a backbone drug in highrisk metabolic patients. Better glycemic control cuts the risk of microvascular complications (eye disease, kidney damage, nerve damage) and macrovascular events (heart attack, stroke) over time. Fewer amputations, fewer cases of kidney failure, and fewer disabling strokes are core drivers of lost lifeyears and compressed healthspan that tirzepatide helps push back against. 3

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Physiological reviews 99(3):13251380 Boyce R, Williams S, Adamantidis A (2017) REM sleep and memory

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Latex-free & hypoallergenic Safe for sensitive skin and allergy-prone users

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