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Some individuals carry genetic markers associated with reduced sensitivity to GLP-1 pathways, meaning standard doses may not produce adequate appetite suppression

Furthermore, the fatigue and joint pain associated with lupus flares can make regular exercise difficult

The treatment involves weekly dose escalation to a maintenance dose of up to 2.4 mg

Mathematical modelling suggests that a system in which the products of one partner, like the glucagon produced by the pancreatic alpha cell, have a stimulatory effect on its counterpart, while the other partners products, like the insulin secreted by the beta cell, have inhibitory effects, enables active regulation to maintain stable levels, something that is indeed mandatory for the control of blood glucose concentration [1,2,3]