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In contrast to vascular endothelial cells in other parts of the body with high permeability, endothelial cells in the BBB lack fenestrations, and there are continuous and dense TJ proteins between cells 59

Acknowledgements The authors disclose support for this work from national funds through the Portuguese Foundation for Science and Technology [CICS-UBI, UIDB/00709/2020 and ProMETAB, 029114 projects

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