GLP-1 and GIP receptors signal through distinct -arrestin 2-dependent pathways to regulate pancreatic cell function
This effectively inhibits colonic inflammation and related histological changes
Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk
This decrease in caloric consumption, combined with potential gastrointestinal side effects such as nausea, vomiting, and diarrhoea, may increase the risk of micronutrient deficiencies in certain individuals
In the ATTAIN-MAINTAIN trial, 205 patients taking tirzepatide and 171 patients taking semaglutide were randomized to take orforglipron or placebo (no active drug) daily for a year