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Different audiences, different evidence, different expectations

Sometimes the issue isn't doing more

These differences could be explained by the study design (retrospective observational study vs prospective randomized trial), selection bias (subjects from the real-world clinical practice are less selected than those included in a clinical trial), drug compliance (subjects enrolled in a clinical trial perform several on site evaluation in which compliance is verified by tablets accounting, while in clinical practice this is not done)

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This individualized approach helps us prioritize safety while supporting long-term progress