Nucleus 1(6):513525 Muchir A, Wu W, Choi JC, Iwata S, Morrow J, Homma S, Worman HJ (2012) Abnormal p38 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation
Mahjani B, Bey K, Boberg J, Burton C
Neuroreport 8(2):475479
Historically the use of copper ionophores such as PBT2 have failed to produce efficacious results in clinical trials (Summers et al., 2022), but crucially they have been investigated without the addition of copper, probably due to the theory that it was primarily to disaggregate copper loaded plaques, in which case PBT2 would act as a chelator (Drew, 2017)
When combined, researchers report improved energy during caloric deficit, better preservation of lean mass, and enhanced metabolic flexibility that neither peptide delivers on its own