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[11] Renal function should be checked if dehydration is suspected

In general, human UGT enzymes apparently exhibit a broad tissue distribution, although the liver is the major site of expression for many UGTs

For example, clinical trials for semaglutide at a 2.4 mg dose showed that 44.2% of participants experienced nausea, compared to 17.4% in the placebo group

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This warning is based on the observance in animal studies of the development of tumors upon administration of semaglutide, but it is unknown if this same complication will affect humans