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Many clients read, answer emails, or simply rest

Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886)

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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase