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Ipamorelin selectively binds to the GHSR-1a receptor, another G protein-coupled receptor involved in growth hormone regulation

[4] [5] It works by mimicking the action of the naturally occurring hormone GLP-1, which is released from the gut after eating

Structural studies have shown that GLP-1R activation involves a complex network of interactions spanning the ECD and the transmembrane (TM) core, including deep penetration of the GLP-1 N-terminus into the orthosteric cavity and stabilization of characteristic active-state rearrangements within the TM bundle (Cong et al., 2022

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