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If you are looking for more practical coping strategies, see our guide to managing semaglutide nausea

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Eating smaller meals, avoiding fatty or spicy foods, and staying hydrated are practical ways to reduce nausea and diarrhea

If you notice these, notify your clinician before adjusting either medication

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus under the brand name Mounjaro and for chronic weight management as Zepbound