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Because of the broad scope required to synthesize Meldonium's historical context, pharmacological mechanisms, and varying international regulatory statuses, it does not employ formal systematic methodologies, such as a PRISMA flow diagram, strict inclusion/exclusion criteria, or standardized risk-of-bias assessment tools

Although designed for pharmaceutical trials, it is useful for the documentation of symptoms and patient-reported outcomes in gastroparesis in general

This contrasts with the experience of nausea, which although still manageable, was the more common reason for dose interruptions or early withdrawal

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