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In mouse models of NASH, GLP-/GIP dual agonists have also been found to significantly reduce TG and LDL-C and increase high-density lipoprotein cholesterol (HDL-C) [127]

Individuals with CKD were on average older, more likely to be male and have a higher burden of cardiovascular disease than those in the main cohort

Luna-MarcoCIannantuoniFHermo-ArgibayADevosDSalazarJDVctorVMet alCardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists through effects on mitochondrial function and oxidative stress

Most patients report minimal to mild discomfort with GLP-1 injections used for type 2 diabetes and weight management

Lancet 383 , 10681083 (2014)