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Insilico Medicine has nominated ISM9528, an orally available, brain-penetrant non-opioid candidate targeting a previously unrecognised pain mechanism, as its 31st AI-generated preclinical compound since 2021, with efficacy exceeding morphine in some preclinical models

The peptide demonstrates excellent bioavailability through multiple administration routes, including subcutaneous injection, oral administration, and even topical application

According to estimates using data from the CHAP study and the U.S