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7 Role of Nuclear Factor Erythroid 2-Related Factor 2 in Breast Cancer Stem Cells The studies found and identified Nrf2 as a major regulator of chemoresistance in cancer stem cell (CSC)-enriched breast cancers (Ryoo et al., 2015) as well as the activation of Nrf2-associated antioxidant genes such as HO-1, NQO1, Prx1, and others that leads to radioresistance in several other cancer cells (Zhou et al., 2013)

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en la actualidad, se est desarrollando terapia sustitutiva enzimtica para el tipo B