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Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means
In some cases, it will be clearly larger beneath the skin, while in other situations, it will be smaller or deeper in the body and only feel noticeable when touched
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This peptide is highly non-selective, which accounts for its diverse range of effects