surmount-1 trial tirzepatide non-diabetic obesity weight loss SURMOUNT-5: Bests Semaglutide in Head-to-Head Shifts in body mass index

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Approximately 1,500 patients with T2D and Early Treatment Diabetic Retinopathy Study (ETDRS) level of 1075 in both eyes and no ocular or intraocular treatment for diabetic retinopathy or diabetic macular edema in the 6 months prior to screening will receive once-weekly subcutaneous semaglutide 1.0 mg or placebo for up to 5 years, with the primary endpoint of progression of 3 steps or more in ETDRS level

It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants

Overall, GLP-1 medications appear to be safe in older adults, and the rate of serious side effects is similar to what we see in younger people

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