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Analysis of candidate cis-regulatory elements (cCREs) has shown that some diabetes-associated variants reduce chromatin accessibility at binding sites for transcription factors such as HNF1A and HNF4A, thereby impairing maintenance of a functional phenotype (Wang et al., 2023)

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A high rate of comorbid immune disorders is also evident, such as Hashimoto thyroiditis and rheumatoid arthritis, and common variable immunodeficiency has been reported in patients with dysautonomia

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It has also been linked to reduced wrinkle depth and thicker skin