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Conversely, a retrospective study with 981 patients with T2DM showed no difference in diabetic retinopathy progression between GLP-1 RAs and SGLT-2 inhibitors [94]

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The change in cAMP signaling could affect both the neuropathology of major depressive disorder in CNS and gastrointestinal epithelial dysfunction in gut (Reierson et al., 2011

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