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N Engl J Med 2023

(Science!) Because of this, theres actually no tolerable upper intake level (UL) for B12 (the max dose you can take before you experience side effects)

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In such a severe case, a specific strategy tailored to the patient was essential, particularly given the lack of success with prior regimens, which seemed to indicate that a more potent treatment regimen was needed in this patient to combat the inflammation upfront