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Combining GLS inhibitors with targeted therapy can suppress glutamine production and asparagine synthesis via their respective metabolic pathways, restoring tumor cell sensitivity to ASNase and significantly reducing asparagine levels, thereby increasing therapeutic efficacy (221)

A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism

Brains of DS individuals exhibit a significant reduction in choline acetyltransferase activity in the cerebral cortex, which is consistent with the impaired development of the basal forebrain cholinergic system exhibited by Ts16 mice [109]

Core-shell supramolecular gelatin nanoparticles for adaptive and on-demand antibiotic delivery