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As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish

Yet GLP-1 receptors are not expressed on liver cells, suggesting that the drugs have an indirect effect: There are no GLP-1 receptors expressed in hepatocytes

Factor #1: Weight loss restores ovulation (sometimes very quickly) The mechanism works like this: Excess body fat produces estrogen and disrupts normal ovulation, while fat cells also produce inflammatory compounds that interfere with reproductive hormones

Common Side Effects For most patients, gastrointestinal side effects are mild to moderate and improve significantly within the first 48 weeks

Certain medical conditions and factors can contraindicate the use of semaglutide, necessitating a careful patient selection process