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IGF-LR3 directly activates IGF-1 receptors in muscle, bone, and metabolic tissues, promoting protein synthesis and tissue repair independent of circulating GH levels

Mai 2019 Finan B, Ma T, Ottaway N et al (2013) Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

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GLP-1 helps regulate blood sugar levels and has been found to play a role in appetite regulation and food intake

FLOW and SELECT show favorable kidney outcomes