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In subjects with renal impairment including kidney failure, no clinically relevant change in semaglutide pharmacokinetics (PK) was observed [see Clinical Pharmacology (12.3)]

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Rare but Serious Concerns: What Research Does and Doesn't Support Thyroid C-cell tumors in animal studies sparked widespread concern, yet decades of human GLP-1 use (dating back to 2005 with exenatide) has not confirmed increased thyroid cancer risk in any sizable cohort