The transformation of AngIV and earlier described analogs into clinically useful agents has been impeded by their lack of metabolic stability and inability to penetrate the blood-brain barrier (BBB)
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7.2 Integration With Lipid Management Statins, ezetimibe, PCSK9 inhibitors, inclisiran, and bempedoic acid remain foundational therapy for atherogenic-lipoprotein reduction
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Mechanistically, because acylcarnitines are direct metabolites derived from fatty acid and organic acid catabolism, disruptions in systemic FAO under metabolic stress, such as during the introduction of enteral feeding in a compromised gut, could theoretically contribute to gut-specific toxicity
