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Proglucagons enzymatic cleavage varies depending on the tissue and is modulated by specific prohormone convertase enzymes

Materials and Methods Experimental Animals and Groups In our study, we raised 120 specific pathogen-free (SPF) grade Wistar male rats (180 20 g weight and 24 weeks old, which is equivalent to 1820 years old in humans) provided by the Experimental Animal Center of the 940th Hospital of Joint Logistics Support force of Chinese Peoples Liberation Army (licence: SCXY (Military) 20120020)