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Clinical Risks of Combining GLP-1 Medications with Cannabis The primary documented risks include unpredictable nausea and vomiting, delayed gastric emptying, impaired glucose monitoring, and potential hepatic stress

After GLP-1 binding, G protein conjugates GLP-1R receptors to activate adenylate cyclase (AC) and increase intracellular cAMP levels

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We have decades of evidence showing that chronic manipulation of enteric signaling (i.e., telling different sections of the digestive tract what to do and when), whether through opioids, supplements, or antidepressants, produces adaptations that outlast the drug itself

Half-life ~6 days