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FIGURE 8 Coordination of curcumin to ruthenium(II) centres can substantially alter its biological behaviour, enabling the exploration of a wide range of pharmacological activities, including anticancer effects, proteasome inhibition, and potential antihyperglycemic activity

MNS-DOX and DNS-DOX were converted by MGST1 and GSTP1-1 via sulfonamide cleavage into the active parent drug (Fig

pylori infection and pancreatic cancer (de Martel et al., 2008

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4 The combination of unresolved biomechanical and biochemical stress promotes secondary alterations which lead to a predominant catabolic microenvironment