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Final Thoughts Tirzepatide represents a substantial step forward in the management of obesity, offering deeper and more consistent weight loss compared to semaglutide

A 60% decline over four decades

Role in managing diabetes and inflammation People with uncontrolled type 2 diabetes produce much less glutathione

Ongoing cohort studies (e.g., NCT06439277) are investigating the efficacy and safety of tirzepatide for weight management in adolescents, though further long-term studies are considered necessary to confirm these findings specifically in patients with MC4R -deficient obesity

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